The FIT-4-NMBP project’s objective is to increase the participation of talented newcomers, promising innovation organisations – especially SMEs – from underrepresented regions in EU-13, EU-15 and Associated Countries in NMBP projects in Horizon Europe, as compared to Horizon 2020. The increase in participation of the talented newcomers will be brought about by connecting them with NMBP hotspots, where important NMBP innovations are demonstrated, as well as networking them with NMBP Top Innovators. From a strategic perspective, FIT-4-NMBP will survey talented newcomers and experts responsible for regional and national R&I policy, in order to understand the precise reasons for non-participation of newcomers in NMBP projects. In turn, best practices will be identified and policy measures formulated and communicated to relevant stakeholders: talented newcomers; regional/national authorities responsible for R&I policy; local innovation and technology transfer nodes; and the EC. From a targeted perspective, the FIT-4-NMBP will: (1) organise innovation workshops between talented newcomers and NMBP Top Innovators; (2) provide hands-on support to talented newcomers to prepare NMBP proposals for Horizon Europe; (3) facilitate networking for talented newcomers at major European conferences and regional brokerage events; (4) provide training to talented newcomers on technology-transfer, proposal writing, and use of European networking portals.